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AstraZeneca’s COVID Antibody Protects Immune-Compromised

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“AstraZeneca, a British-Swedish multinational pharmaceutical and biotechnological company based at Cambridge Biomedical Campus in England, is confident that its new version of COVID-19 antibody treatment is capable of protecting immunocompromised patients against all marked virus variants.”

During the first wave of COVID, many companies proposed their own version of COVID vaccines and AstraZeneca is one of them. It is a British-Swedish multinational pharmaceutical and biotechnological company based at Cambridge Biomedical Campus in England. 

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The pharma company has developed a new version of COVID-19 antibody treatment. The company is confident that this new treatment is capable of protecting immunocompromised patients against all marked virus variants.

According to reports, the company plans to make its antibody available by the end of 2023. This is because of pending regulatory approval and the need for more positive data.

Iskra Reic, Executive Vice President, said, “Laboratory studies show the antibody, called AZD3152, neutralizes all known variants of COVID-19 and AstraZeneca has support from regulators to make the treatment available by the end of this year”

Antibody therapies have become a must for people whose immune systems are compromised. This can be due to undergoing immunosuppressive treatments or having underlying health conditions. These people account for approx 2 percent of the global population.

January 2023, the U.S. health regulator revoked the emergency use authorization of the pharma company’s original COVID-19 antibody cocktail, Evusheld. The reason cited for the revocation was the emergence of new dominant variants of the virus.

The U.S. Food and Drug Administration‘s (FDA) decision matched the concerns which were raised by the health regulator of Europe. 

The multinational pharma company developed a new COVID-19 antibody called AZD3152. Last year, the British biotech startup RQ Bio acquired AZD3152 in a deal worth $157 million.

Iskra Reic also said, “Iskra Reic also said, “The British drugmaker will likely make future investments like its current partnerships with RQ Bio. However, the company did not have any deals to announce at present.”

Low Breastfeeding Rates Found in Infants Born to COVID-19 Affected Mothers: Health Study

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“The combined global study of Murdoch Children’s Research Institute and The European Society of Paediatric and Neonatal Intensive Care (ESPNIC) found that the transmission of COVID-19 from mothers to babies was uncommon and typically modest when it did occur.”

A global investigation observed that when the pandemic was at its peak, skin-to-skin contact and breastfeeding rates were low as the majority of infants born to mothers with COVID-19 were kept apart after birth.

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The combined global study of Murdoch Children’s Research Institute and The European Society of Paediatric and Neonatal Intensive Care (ESPNIC) found that the transmission of COVID-19 from mothers to babies was uncommon and typically modest when it did occur.

Yet, 25% of babies were nursed, and most mothers and infants were not in contact right after birth. Around 50% of infants didn’t get their mothers’ breast milk.

Professor David Tingay, Murdoch Children’s Research Institute, said, “the largest on global family-centered care during COVID-19, highlighted how ensuring suitable infection control measures had significantly impacted neonatal practice over the past few years.

Almost half of all newborns in the trial were denied early and close contact with their mother, demonstrating how hard it was to balance infection control measures with mother-baby bonding recommendations, especially in the first year of the pandemic,” he said.

Encouragingly, clinicians did gradually adapt to allow more family-centered care as the pandemic progressed, particularly using breastmilk.”

The study was done on 692 babies born to mothers with SARS-CoV-2. It is held in 13 neonatal intensive care units in 10 countries that include the US, France, Italy, and Brazil. The study was published in The Lancet’s e clinical medicine.

The study also found that 54% of infants were contactless and only 7% had physical contact before separation. Breastfeeding rates were low and were 53% and 24% exclusively fed with their mother’s breast milk.

Changes in the field of Technology post Covid-19

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In the peak of the COVID-19 pandemic, when Zoom saw a daily average of roughly 200 million participants. The company attributes the continued growth to the increasing demand for remote work and online education, as well as its efforts to improve security and privacy features.

In the healthcare industry, technology continues to play a crucial role in the fight against the COVID-19 pandemic. Pharmaceutical company Moderna announced that its COVID-19 vaccine has been found to be effective in children as young as 12 years old, following clinical trials. This news is seen as a major step forward in the efforts to vaccinate and protect younger age groups, who have generally been less affected by the virus.

On the sustainability front, tech giant Google announced that it had achieved its goal of becoming carbon neutral, meaning that it has offset all of its carbon emissions from its operations. The company accomplished this through a combination of reducing its own emissions and purchasing carbon credits. Google also announced that it will now aim to become “carbon-free,” meaning that it will eliminate all carbon emissions from its electricity use by 2030.

Overall, technology continues to advance and make significant impacts across various industries and aspects of daily life. From new product releases and virtual event platforms to healthcare solutions and sustainability efforts, the role of technology in society shows no signs of slowing down.

Technology has played a significant role in the response to the Covid-19 pandemic, including in the development and distribution of vaccines, the creation of contact tracing apps, and the shift to remote work and online learning.

One of the ways that technology has been used in the response to Covid-19 is through the development and distribution of vaccines. Many pharmaceutical companies have used technology to accelerate the development and production of vaccines, including through the use of advanced data analytics and artificial intelligence.

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Study found a link between heart condition and Covid

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According to a study there is a link between heart condition and Covid. Researchers at Cedars-Smidt Sinai’s Cardiac Institute found that there is a connection between a debilitating heart condition and Covid-19, as well as a new link between the same condition and the Covid-19 vaccine.

 

Findings

According to The Tribune, “Their findings, published in the peer-reviewed journal Nature Cardiovascular Research, suggest that a small percentage of patients vaccinated against Covid-19 may develop postural orthostatic tachycardia syndrome, or POTS. The investigators also found that those diagnosed with Covid-19 are five times more likely to develop the same cardiac condition after infection than after vaccination, emphasizing the importance of the vaccine.”

“The main message here is that while we see a potential link between Covid-19 vaccination and POTS, preventing Covid-19 through vaccination is still the best way to reduce your risk of developing POTS,” said Alan C. Kwan, MD, first and corresponding author of the study and a cardiovascular specialist at Cedars-Sinai.

The Tribune also said, “Postural orthostatic tachycardia syndrome is a nervous system-related condition that most commonly affects young women of childbearing age. The most identifiable POTS symptom is a rapid increase in the heartbeat of more than 30 beats per minute, or a heart rate that exceeds 120 beats per minute, within 10 minutes of standing. Other symptoms include fainting, dizziness and fatigue, although some patients with severe disease may also experience migraine, increased urination, sweaty extremities, anxiety, and tremor.”

“From this analysis, we found that the odds of developing POTS are higher 90 days after vaccine exposure than the 90 days prior to exposure,” said Kwan. “We also found that the relative odds of POTS were higher than would be explained by increases in visits to physicians after vaccination or infection.” Kwan emphasizes that despite this finding, the rates of POTS after vaccination were much lower than rates of new POTS diagnosis after Covid-19.

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Days of wearing masks are coming back

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Though people thought that days of wearing masks are gone, the days of wearing masks are coming back with Flu and RSV contamination.

According to NBC News, “Entering the holiday season last year, surging Covid-19 cases overwhelmed hospitals. This year, hospitals have been overwhelmed by a combination of Covid, respiratory syncytial virus (RSV) and the flu. Along with RSV, the record number of flu cases pushing pediatric hospitals near to capacity is a worrisome signal that the current flu season will be the worst in years. Facing a particularly acute crisis, pediatric hospitals have called upon President Joe Biden to declare an emergency to provide more resources to respond to the current surges.

This “tripledemic” of flu, Covid and RSV is a reminder that even as the pandemic ends, the threat of seasonal respiratory viruses remains. Thankfully, our toolkit for tackling them is similar to what works to suppress Covid alone, starting with the most basic and flexible level of protection: masking. When and where respiratory viruses are surging, mask mandates should be reinstated.”

 

Statistics

They also said, “In a typical year, RSV causes up to 80,000 hospitalizations and 300 deaths among children under 5, and up to 10,000 deaths and 120,000 hospitalizations among adults age 65 and older. As with flu and now Covid, individual adverse outcomes are rare relative to the number of cases, but more spread and more infections means more people experience serious outcomes. Even with the pandemic receding, an average of 300 people are still dying from Covid every day. Unvaccinated people face six times the risk of death according to recent data, but many people dying now are vaccinated as well.”

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Rising number of Covid-19 patients are concerning the experts

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Suddenly, there have been seen a increase in covid-19 patients at U.S. hospitals arriving even as health systems contend with waves of feverish, coughing people stricken with RSV and influenza infections.

 

Increasing number of Patients

According to Washington Post, “Covid hospitalizations last week reached their highest level in three months, with more than 35,000 patients being treated, according to Washington Post data tracking. National hospitalizations had stagnated throughout fall but started rising in the days leading up to Thanksgiving. All but a few states reported per capita increases in the past week.

Public health authorities are concerned that the increase in the number of covid patients will worsen the strain on hospitals already under pressure from the effects of two other viral ailments, influenza and respiratory syncytial virus, widely known as RSV.”

 

Experts Observation

“It could be in a week or two we are seeing many more covid patients than we are seeing RSV or flu, but the real concern is we will see a large influx of all of them really stressing out the hospitals’ capacity to care for these very sick patients,” said Foster, the association’s vice president of quality and patient safety policy.

“If we are going to see a big surge, it’s going to start to ramp up now, and it’s going to extend and probably peak in late December and early January,” said Columbia University epidemiologist Jeffrey Shaman. “The hope will be it will be somewhat mild, of course, and enough boosting and prior exposure is going to keep a large chunk of people out of the hospital.”

“What is happening this winter already and what we can continue to expect is influenza and RSV are not going to be at unprecedented low levels,” said Banner Chief Clinical Officer Marjorie Bessel. “We are going to have a high-volume winter like we have had previously in the pandemic. How much of a high volume due to all this coming together is an unknown.”

For more updates on healthcare industry, Click here.

Symptoms of Flu. Covid and RSV in kids

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In post Covid-19 time it is very important for parents to know the exact symptoms of different diseases like normal flu, Covid-19 or RSV.

When the children come home with a runny nose, if the parents know the symptoms, it will be easy for them to take steps.

 

RSV symptoms in kids

RSV is very contagious and a common illness in children, with most having had an RSV infection by their second birthday, per the Centers for Disease Control and Prevention.

The symptoms include a runny nose, decrease in appetite, coughing, sneezing, fever and wheezing, per the CDC.

Most RSV infections go away within a week or two, but the CDC recommends parents call their healthcare provider if their child “is having difficulty breathing, not drinking enough fluids, or experiencing worsening symptoms.”

The symptoms of RSV usually come on gradually and they show up within 4 to 6 days after becoming infected.

 

Flu symptoms in kids

Symptoms of the flu typically come on suddenly, which is perhaps its biggest distinction from RSV, per Health Partners.

Flu symptoms can include fever, cough, sore throat, runny or stuffy nose, body aches, headache, chills, feeling tired and sometimes vomiting and diarrhea, per the CDC.

Flu symptoms typically develop about 1 to 4 days after being exposed to a sick person.

“Even healthy children can get very sick from flu,” the CDC warns.

The CDC says that parents should take their children to the emergency room if they are experiencing fast or trouble breathing, bluish lips or face, ribs pulling in with each breath and chest pain, among other symptoms.

 

COVID-19 symptoms in kids

The most common symptoms of COVID-19 in children include fever and cough, but children can also experience sore throat, headache, fatigue or gastrointestinal symptoms, per the CDC.

Be smart: One of the best ways to protect your family is to stay up-to-date on your flu and COVID shots.

The CDC also recommends parents get their child tested if they develop symptoms, as that is the best way to know whether it is the flu or COVID-19.

For more updates on pharma and life science, Click here

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